It has been previously documented that a non-inflammatory process is associated with the pathogenesis of the disease [13], however, current studies found evidence of cytokines and inflammatory markers as interleukins (IL-1, IL-6, IL-8) and tumor necrosis factor alpha (TNF-α) in the tear-film of patients with keratoconus [14]. The gene discussed is TNF; the disease is keratoconus.