SERPINE1 and glaucoma: TGF-β2 has been shown to induce nuclear YAP/TAZ localization and the consequent activation of target genes (which are correlated with the development of glaucoma), including TGM-2, CTGF, and plasminogen activator inhibitor-1 (PAI-1), via ERK and ROCK signaling pathways in response to mechanical signals (Figure 2(c)) [59, 65, 66].