Last but not least, apoptosis pathway (ACTB, ATM, HSPA8, SFRS1, TNF, UBE2I), DNA damage and metabolism of RNA (CDC42, JUN, POLR2B, SMARCA4, DHX15, EPRS, HNRNPA1), and cell cycle process (ATM, POLR2B, UBE2I, VEGFA) can play roles in hepatocellular necrosis and cellular infiltration in the liver organ of patients with COVID-19, resulting in liver apoptosis [79]. The gene discussed is UBE2I; the disease is COVID-19.