Last but not least, apoptosis pathway (ACTB, ATM, HSPA8, SFRS1, TNF, UBE2I), DNA damage and metabolism of RNA (CDC42, JUN, POLR2B, SMARCA4, DHX15, EPRS, HNRNPA1), and cell cycle process (ATM, POLR2B, UBE2I, VEGFA) can play roles in hepatocellular necrosis and cellular infiltration in the liver organ of patients with COVID-19, resulting in liver apoptosis [79]. This evidence concerns the gene POLR2B and COVID-19.