Additionally, a combined effect of genetic variants in genes responsible for the synthesis of proinflammatory cytokines/chemokines along with ACE2 has been suggested to be responsible for differences in patients' response to COVID-19 in terms of hypercytokinemia/cytokine storm that characterized by excessive proinflammatory cytokine production associated with multiple organ failure [76]. The gene discussed is ACE2; the disease is COVID-19.