Therefore, since the better understanding of the gene–diet interactions can provide more efficient strategies for personalized treatment, and also as far as we know, no previous evidence is available on the modification effect of diet in terms of dietary antioxidant capacity on the association of CARTPT gene with obesity-related metabolic factors, the aim of the present study was to assess the potential interactions of CARTPT rs2239670 with NEAC intake in relation to cardio-metabolic risk factors among obese population. The gene discussed is CARTPT; the disease is obesity disorder.