GSTM1 and hypercalcemia disease: Most of our patients who had hyperdiploidy significantly presented with elevated Hb level, low calcium levels, were staged as stage I and II ISS and considered as standard risk group, therefore showed better response to treatment Table 1 and those with del 13 q, their clonal plasma cells showed significant lambda chain restriction (P value < 0.05), while patients who harbored 17 p deletion were significantly presented with hypercalcemia and considered as stage III ISS and RISS; hence, they showed poor response to treatment as shown in Table 1.