Also, the effect of MK-2206 on the ABCG2 ATPase was determined in High-five insect cells and not in cancer cells and thus, it is possible that the effect of MK-2206 on ABCG2 ATPase in cancer cells may be different from that of the High-five insect cells, although this remains to be determined. The gene discussed is ABCG2; the disease is cancer.