In this study, our results indicated that MK-2206, at 0.3 and 1 μM, did not significantly decrease the viability of the parental H460 and ABCG2-overexpressing H460/MX20 lung cancer cells and parental S1 and MDR ABCG2-overexpressing S1-M1-80 colon cancer cells. This evidence concerns the gene ABCG2 and lung carcinoma.