Whereas in the low-risk group, cancer antigen presentation (Step 2), priming and activation (Step 3), trafficking of immune cells to tumors (Step 4, such as CD4 T cell, CD8 T cell, NK cell, dendritic cell, B cell, Treg cell, and TH1 cell), infiltration of immune cells into tumors (Step 5), and killing of cancer cells (Step 7) were stronger than that in the high-risk group. Here, CD4 is linked to cancer.