Moreover, researchers used gene enrichment analysis and found that the carbohydrate metabolic process, fatty acid metabolic process, lipid biosynthetic process, and response to hypoxia were associated with aurora kinase inhibition in Th-MYCN transgenic NB mice, which would simultaneously have potential effects on the regulation of autophagy and ferroptosis (Lu J. et al., 2021; Chen et al., 2021c; McLeod et al., 2021; Ni et al., 2021; Wang et al., 2021). This evidence concerns the gene MYCN and neuroblastoma.