Since the functional enrichment results have revealed a close relationship with metabolism, autophagy, and immunity, ssGSEA was performed, which showed that there were more active immune components in the microenvironment of NBs in the low-risk group, such as activated CD8 T cell, natural killer cell, and neutrophil cell, providing us with the possibility of low-risk patients being included in the “hot tumor” group. Here, CD8A is linked to Nijmegen breakage syndrome.