MAPT and Alzheimer disease: In another study employing a fly model of tauopathy, Amph knockdown was observed to reduce tau-induced actin inclusions (Drager et al., 2017), a feature of tau pathophysiology, consistent with evidence that Bin1 exerts actin bundling and filament stabilizing effects (Prendergast et al., 2009) that are altered in various neurological disorders, including AD.