BIN1 and neurodegenerative disease: By this route, we accumulated evidence that Bin1 acts as a modifier of disease severity in many settings, including cancer, cardiac arrhythmia, heart failure, inflammatory bowel disease (IBD) and neurodegenerative disease (Muller et al., 2003; 2004; Chang et al., 2007a; 2007b; 2012; Laury-Kleintop et al., 2015; Miyakawa et al., 2016).