In another study employing a fly model of tauopathy, Amph knockdown was observed to reduce tau-induced actin inclusions (Drager et al., 2017), a feature of tau pathophysiology, consistent with evidence that Bin1 exerts actin bundling and filament stabilizing effects (Prendergast et al., 2009) that are altered in various neurological disorders, including AD. This evidence concerns the gene MAPT and tauopathy.