ACE and Stroke: Drug targeting metabolic syndrome focus on reducing blood pressure and blood glucose levels, and include medications such as angiotensin-converting enzyme (ACE) inhibitors (such as Capoten and Vasotec) for blood pressure, cholesterol medications (3) such as statins, niacin, and Zetia, medications for treating diabetes, such as metformin (Glucophage), pioglitazone (Actos), and rosiglitazone (Avandia) (4), and low-dose aspirin, which can reduce the risk of heart attack and stroke.