The CHD7 variant is reported at an extremely low frequency in the reference population database gnomAD v2.1.1 (accessed on 2023/02/28), predicted damaging by most in silico tools, and can be classified as a variant of uncertain significance (VUS) favoring likely pathogenic, possibly contributing to a subset of the reported clinical features (i.e., asymmetric face and monolateral choanal atresia). This evidence concerns the gene CHD7 and choanal atresia.