In a proteomics analysis of Aβ accumulation in blood vessels of cases with cerebral amyloid angiopathy (CAA) in the occipital/parietal lobes, one of the top altered proteins was high-temperature requirement serine peptidase 1 (HTRA1) which is suggested to remove misfolded or mislocalized peptides in an ATP-independent manner (102). Here, HTRA1 is linked to cerebral amyloid angiopathy.