NEDD8 and psoriasis: However, using each of these thresholds, the largest network component extracted from our GNN was centered about the same network hub reaction Reactome:R-HSA-8956184: 26S- and NUB1-mediated degradation of NEDD8, UBD, and their conjugates (https://reactome.org/content/detail/R-HSA-8956184), which is a central component of the neddylation pathway linked to psoriasis in the literature.