For example, QIN G et al. found that the enhancement of the interaction between p53 and heterogeneous ribonucleoprotein K could be achieved by the combination of lncRNA-PSTAR and heterogeneous ribonucleoprotein K, which further leaded to the accumulation and transactivation of p53 and induced cell cycle arrest to restrain the proliferation and metastasis of HCC cells [40]. This evidence concerns the gene TP53 and hepatocellular carcinoma.