Consistent with the results of this study, another study [33] also implied that MKLN1-AS was up-regulated in HCC tissues and the cell lines, which could increase hepatoma derived growth factor (HDGF), thereby restraining tumor cell apoptosis and boosting the proliferation, migration and invasion of HCC, and then being distinctly interrelated to the shortening of the overall survival of patients. The gene discussed is HDGF; the disease is hepatocellular carcinoma.