E2F8 and hepatocellular carcinoma: Among them, E2F1 inhibited c-Myc-induced apoptosis through PIK3CA/Akt/mTOR pathway while E2F8 increased the proportion of S-phase cells by up-regulating the expression of cyclinD1, next promoted the occurrence and development of HCC [[42], [43], [44], [45], [46]].