In the classic pathway, similar to the results of the KEGG and GO enrichment analysis, the cell cycle control members such as E2F targets, G2M checkpoint, and mitotic spindle are enriched, while the cancer gene pathway is enriched in HOXA9, PRC2-EED, SNF5, VEGF-A, and PRC2-EZH2 etc. There is already a lot of evidence to verify the role of these pathways or genes, as show below. This evidence concerns the gene EED and cancer.