Polymorphism rs1803274 is associated with an increased risk of coronary restenosis (15), Alzheimer's disease (16), tumorigenesis (17) and metabolic risk factors (cardiovascular, obesity, blood pressure, and diabetes) (18).This study was aimed to assess the frequency of BCHE polymorphisms, responsible for reduced BCHE activity in patients undergoing surgery in Slovakia. This evidence concerns the gene BCHE and early-onset autosomal dominant Alzheimer disease.