In particular, Vignoli A et al., in their study found that patients with ER (+) breast cancer not only had an escalation of several T cell triggering factors such as IL12-p70, TNF- α; but also showed an increase level of several cytokines that suppress the work of T-cells such as IL-10, IL-8 and TGF-1 as well as a decrease in both T-cell activating factors (IL-1α and IL-2). The gene discussed is TNF; the disease is breast cancer.