The mechanism of PRP in ovarian activity resurgence attributes to increases in concentrations of PDGF, TGF-β, IGF-1/2, VEGF, and EGF which result in increasing the number and maturation of preantral follicles, as well as rising in serum level of AMH in infertile women older than 40 years with premature ovarian insufficiency (15,16). The gene discussed is IGF1; the disease is premature menopause.