NUP98 and acute myeloid leukemia: More than 50% of pediatric and adolescent acute myeloid leukemia (AML) cases are characterized by chromosomal rearrangements that give rise to leukemic fusion genes.1 Translocations of the Nucleoporin 98 (NUP98) gene are among the most common recurrent translocations in pediatric AML, representing 4% of all fusion events.