We first examined the impact of Menin inhibition on cells transduced with NUP98::NSD1 and NUP98::DDX10 fusion genes.24 Revumenib suppressed cell proliferation of both transduced AML cell lines in a dose-dependent fashion with IC50 values of 56 and 36 nM, respectively (Suppl. Here, NUP98 is linked to acute myeloid leukemia.