However, the study identified another PDX model with additional mutations (ASXL1, IDH1, BCORL1, WT1, and FLT3-ITD) that did not respond to Menin inhibition, indicating that certain mutations or their combinations may confer resistance to Menin inhibition.20FLT3-ITD and WT1 are the most prevalent concurrent secondary genetic alterations in this AML subtype, and their cooccurrence with NUP98 fusions confers a poor prognosis.2,3,21,22,45,46. This evidence concerns the gene ASXL1 and acute myeloid leukemia.