More than 30 gene partners have been reported for NUP98 in a wider range of AML subtypes including monocytic, megakaryoblastic, and erythroid AMLs, with NUP98::NSD1 and NUP98::KDM5A as the most prevalent.2,3,7,8 The resulting fusion proteins promote leukemia by recruiting various chromatin regulatory proteins, leading to the transcriptional activation of leukemia-associated genes.9–11. Here, NSD1 is linked to acute myeloid leukemia.