NPM1 and acute myeloid leukemia: These data show that Menin inhibition can target FLT3 expression in line with similar observation reported for MLL-r and NPM1-mut AMLs.16,27 Because all tested NUP98::NSD1 AML cells were positive for FLT3-ITD with allelic frequencies above 0.4, we also evaluated the impact of Menin inhibition on the expression of the mutated allele.