However, considering the diversity of fusion partners, which fall into distinct leukemia phenotypes such as AMKL (NUP98::JARID1A) and the variety of epigenetic regulatory domains in this AML type, more samples are required to be tested to determine if all NUP98-r AMLs are dependent on the MLL–Menin interaction. This evidence concerns the gene KMT2A and acute myeloid leukemia.