BCORL1 and acute myeloid leukemia: However, with respect to the BCORL1 mutation, recent studies have suggested that it dynamically competes with NUP98 fusions for transcriptional regulation of developmentally regulated, stem cell-associated genes as a component of the polycomb repressive complex (PRC) 1.1.47 Nonetheless, BCORL1 mutations are uncommon in NUP98-r AML and are poorly understood.