As the expression of these genes was shown to be dependent on a functional MLL–Menin interaction,10 we examined the impact of inhibiting this interaction on the expression of HOXA7-10 and the genes coding for MEIS1 and PBX3 in both NUP98::NSD1- and NUP98::TOP1-positive primary AML cells. Here, NSD1 is linked to acute myeloid leukemia.