An interesting model, which can be considered a hybrid between scaffold-free and scaffold-based, has been developed by Spelat et al, who wanted to integrate an MM culture and a 3D microenvironment while maintaining malignant cells in their natural floating condition.42 They observed that this interaction led to a different MM cell behavior when compared with 2D cultured cells, highlighting an overexpression of CX3CR1, involved in the axis CX3CL1/CX3CR1, which supports cooperation between malignant cells and the microenvironment.42 This evidence concerns the gene CX3CR1 and Miyoshi myopathy.