Another explanation is that these combinations are sufficient to restore readthrough in other genes, but not NF1. Additionally, we had a small sample size of primary Schwann cell cultures with LOH, and future in vitro studies would be strengthened by evaluating multiple cell types of interest in NF1, including other cells that undergo LOH, like melanocytes associated with CALMs and oligodendrocytes associated with optic pathway glioma. The gene discussed is NF1; the disease is optic pathway glioma.