In mice, chronic mild stress (CMS) increased expression of some miRNAs in the PFC (miR-9-5p, miR-128-1-5p, and miR-382-5p) [167] that target Drd2, Clock, Map2k, Mapk1, and Bdnf genes [168–170], all related to the physiopathology of depression. The gene discussed is BDNF; the disease is major depressive disorder.