Eight biomarkers demonstrated significant relevance for patients that progressed from MCI to dementia due to AD, including MCP-1 (63), neuronal pentraxin 2 (NPTX2), OPN, YKL-40 and several TNF receptors (with related proteins that were also part of a composite score) (Table 4A). This evidence concerns the gene CHI3L1 and Alzheimer disease.