Moreover, the BCR sequences of self-reactive B cells identified within an individual or across autoimmune subjects can be queried for the identification of a “public” (i.e. shared) BCR V(D)J sequence among autoimmune subjects, similar to what has been found with some T cells in autoimmune diseases, including Celiac disease, T1D, and RA (48–51). This evidence concerns the gene BCR and type 1 diabetes mellitus.