A randomized controlled trial included 207 melanoma patients treated with anti-CTLA-4 plus chemotherapy, as well as one retrospective cohort with 331 melanoma patients treated with anti-PD-1/PD-L1 monoantibodies, also corroborated the positive correlation between obesity and prolonged PFS and OS, and the association was mainly seen in male patients, while no significant difference was observed in female patients (47). The gene discussed is CTLA4; the disease is melanoma.