Furthermore, reduced expression of the arginine methyltransferase coactivator-associated arginine methyltransferase 1 (CARM1) in COPD bronchial epithelial cells is associated with increased senescence, and impaired club cell regeneration and epithelial repair, possibly through altered histone methylation of cell cycle and differentiation genes (184, 185). This evidence concerns the gene CARM1 and chronic obstructive pulmonary disease.