In details, the IFNG methylation level decrease was observed in participants with any allergy (HK-W=5.359, p=0.021), the IL10 methylation level was lower among FA+ADFA patients (HK-W=5.116, p=0.024), whereas the FOXP3 methylation level was higher among those with ADFA (HK-W=4.670, p=0.031), while smoking exposure was taking place after the birth of an infant. This evidence concerns the gene IL10 and allergic disease.