Quantitative comparative analyses show that the most significant effects of endotoxemia were early SUMO1 signals at 100 and 150KDa, and late p250 and early SUMO2/3 signal at 70KDa, and late 260KDa smear (Figures 4E, F; Supplementary Figures 3C, D). Here, SUMO1 is linked to serum lipopolysaccharide activity.