MMP9 and neoplasm: Furthermore, it has been demonstrated that stable overexpression of ANXA5 in non-Hodgkin’s lymphoma cell lines could inhibit cell invasion through decreasing MMP-9 expression and ANXA5 knockdown using specific shRNA increased MMP-9 activity and tumor cell invasion; this supports the possible role of ANXA5 in inhibiting invasiveness characteristics of these tumor cells [13].