Analysis of the real-time PCR data showed that ANXA5 overexpression could decrease the MMP-9 expression, indicating that the decrease in the expression of MMPs might be involved in the observed anti-invasive effects of ANXA5. In accordance with our data, suppressing effects of ANXA5 on MMP-9 expression has been revealed in cervical cancer lines [19]. Here, MMP9 is linked to cervical cancer.