Conversely, in some tumor cells such as oral carcinoma cells [20] and murine hepatocarcinoma cells [21], as well as several normal cells including human keratinocytes [22] and corneal epithelium [23], ANXA5 upregulation has increased cell migration, suggesting diverse effects of ANXA5 in different cell types. This evidence concerns the gene ANXA5 and lip and oral cavity carcinoma.