One study evaluated LTA4H genotype in TB-IRIS in an Indian cohort of 142 patients with newly diagnosed TB and low CD4 cell counts; it found an association between genotype and incidence of TB-IRIS, though only for severe TB-IRIS (defined as a Karnofsky score of ≤50 or a clinical condition mandating hospitalization or prolonging of hospital admission) [6]. Here, CD4 is linked to tuberculosis.