In KSHV-infected HMGB1 KO cells, we did not observe any alteration in the viral gene expression of KSHV compared to that in KSHV-infected WT cells, indicating that both WT and HMGB1 KO cells showed latent infection in KSHV-infected cells. The gene discussed is HMGB1; the disease is disease arising from reactivation of latent virus.