MFN2 and acute lymphoblastic leukemia: The survival of T-ALL cells after DOX treatment was correlated with the expression of Mitofusin-2 (MFN-2)—A GTPase protein that mediates mitochondrial fusion—With an increase in the expression of CTE complexes as well as a proportional increase in oxygen consumption rate (OCR), and increased sensitivity to DOX was evident upon inactivating MFN-2 by CRISPR (Decker et al., 2020).