Additionally, Nan et al. (2022) in a group with high-risk AML identified an increased mitochondrial gene signature: electron transfer flavoprotein subunit beta (ETFB), carnitine palmitoyl transferase 1A (CPT1A), 4-Hydroxyphenylpyruvate Dioxygenase Like (HPDL), and isocitrate Dehydrogenase NAD+ 3 Catalytic Subunit Alpha (IDH3A) (Jiang et al., 2022). This evidence concerns the gene HPDL and acute myeloid leukemia.