CD8A and neoplasm: Furthermore, in the 4T1 murine breast cancer model, extracts derived from T. usneoides and P. nigrum modulate the immune response by increasing the frequency of DC and activated CD8+ T cells and decreasing myeloid-derived suppressor-like cells (MDSC-LCs) and regulators T cells (Tregs) in the tumor microenvironment, thus favoring control of tumor growth (Lasso et al., 2022).