The phosphoinositide 3-kinase-Akt-mammalian target of rapamycin (PI3K-Akt-mTOR) signaling pathway, commonly activated in cancer, including AML, contributes to the maintenance of glycolysis by translational and post-translational regulation of metabolic enzymes (Hoxhaj and Manning, 2020; Nepstad et al., 2020). The gene discussed is MTOR; the disease is acute myeloid leukemia.