The mRNA levels of ACTG1, CALM3, COL1A2, RPL27A, HNRNPA2B1, CLU, PTMA, PPP2CA, C1S, SERPING1 and LTBP2 were higher in IDD groups than in healthy control in both NP tissues and AF tissues. This evidence concerns the gene CLU and intervertebral disk degenerative disorder.