Restoration of hepatic IGF-1 expression via transgene (1) normalized serum GH, glucose homeostasis, and serum lipid; (2) decreased but did not normalize hepatic steatosis, DNL, or hepatic lipid uptake; (3) did not affect enzymes involved in oxidative stress or inflammatory cytokines but did normalize ALT, AST, and lipid peroxidation. The gene discussed is IGF1; the disease is fatty liver disease.