IREB2 and heavy chain disease: However, the qPCR analysis of lipolysis genes showed that the expression levels of hepatic hormone-sensitive lipase (hsl) and carnitine palmitoyl transferase 1a (cpt1a) were significantly increased in HCD group at 6th and 8th week, while acyl-CoA oxidase 3 (aco3) significantly increased in HCD group only at 8th week, compared to those in NCD group (P < 0.05) (Figure 3(d)–3(f)).