The immunostaining of hepatic SREBP1 showed that the percentage of SREBP1 positive hepatocytes and the fluorescence intensity of SREBP1 were significantly increased in HCD group at 4th, 6th, and 8th week, compared to those in NCD group (P < 0.05) (Figure 4(a)–4(c)). The gene discussed is SREBF1; the disease is heavy chain disease.