SREBF1 and heavy chain disease: Within HCD group, the percentage of SREBP1 positive hepatocytes and the fluorescence intensity of SREBP1 were significantly increased at 4th, 6th, and 8th week, compared to those at 2nd week (P < 0.05); however, they were both significantly decreased at 8th week, compared to those at 6th week (P < 0.05) (Figure 4(a)–4(c)).