MLXIPL and heavy chain disease: Within HCD group, the percentage of ChREBP positive hepatocytes and the fluorescence intensity of ChREBP were significantly increased at 6th and 8th week, compared to those at 2nd and 4th week (P < 0.05); however, there was a further increase in the percentage of ChREBP positive hepatocytes at 8th week, compared to those at 6th week (P < 0.05) (Figure 6(a)–6(c)).Within NCD group, the percentage of ChREBP positive hepatocytes and the fluorescence intensity of ChREBP were also significantly increased at 6th and 8th week, compared to those at 2nd and 4th week (P < 0.05) (Figure 6(a)–6(c)).