Furthermore, compared to the negative control group, DNAJC1 knockdown in Huh7 and MHCC97H cells promoted the expression of p21, p53, p-p53(Ser20), Bax and E-cadherin proteins, while inhibiting the expression of PARP, MMP9, Vimentin, Snai1, Bcl-2 and N-cadherin proteins.<h4>Conclusions</h4>DNAJC1 had a predictive value for the prognosis of HCC. Here, TP53 is linked to hepatocellular carcinoma.