PTGS2 and rheumatoid arthritis: The pathophysiology of rheumatoid arthritis is still unknown, but researchers have speculated that inflammatory intermediator, such as tumor necrosis factor-alpha, cyclooxygenase-2, and interleukin-6 are involved in the inflammatory response of synovial membranes and bone injury observed during rheumatoid arthritis (Meehan et al., 2021).