PIK3CA and cancer: In addition, functional enrichment analysis revealed that the common signaling genes for four cancer datasets are involved in significant biological processes or pathways, for instance, the cell cycle (Hartwell & Kastan, 1994), PI3K-Akt signaling pathway (Martini et al., 2014), spliceosome (Yang, Beutler & Zhang, 2022), Wnt signaling pathway (Zhou et al., 2022) (Fig. 5).