Moreover, as high adenosine surges occurred during ECT and several hints point toward an involvement of the purinergic system in mood disorders, other targets like the adenosine A2A adenosine receptor (A2AAR), the ATP receptor P2X7 as well as interactions of the A1AR/A2AAR and the adenosinergic and dopaminergic system warrant further investigations. This evidence concerns the gene ADORA2A and mood disorder.