For patients not receiving intravenous recombinant tissue-type plasminogen activator (rt-PA), endovascular treatment and with no compelling medical condition to dictate acute BP lowering therapy, BPs up to 220/120 mmHg may be observed without BP lowering therapy in the first several days according to the latest American Heart Association/American Stroke Association [AHA/ASA] (2022) guidelines. This evidence concerns the gene PLAT and Stroke.