ESAM and Alzheimer disease: Among the 32 differentially expressed proteins, Rab35, Rab3a, Tcp1, Gstm1, Rack1, Il1rap (ASD) (36–40), Ccdc60, Esam (schizophrenia) (41, 42), and Psmb6 (Alzheimer's disease) (43) are associated with various nervous system disorders.