Among the 32 differentially expressed proteins, Rab35, Rab3a, Tcp1, Gstm1, Rack1, Il1rap (ASD) (36–40), Ccdc60, Esam (schizophrenia) (41, 42), and Psmb6 (Alzheimer's disease) (43) are associated with various nervous system disorders. This evidence concerns the gene ESAM and early-onset autosomal dominant Alzheimer disease.