NR3C1 and Anxiety: Several previous studies demonstrated that the offspring of the L-NAME-induced PE model rats showed various abnormal neuropathological findings including neurotoxicity, upregulated expression of hippocampal glucocorticoid receptors, disrupted neurogenesis, and acute neuronal damage (27–30); however, little is known regarding whether this L-NAME-induced PE model indeed shows changes in anxiety, cognition, and memory-related behaviors.