We herein compared plasma concentrations of endothelial activation biomarkers vascular endothelial growth factor (VEGF), hyaluronan (HA), plasminogen activator inhibitor-1 (PAI-1) and von Willebrand factor (vWF), as well as inflammatory mediator concentrations (IL-6, IL-8, IL-10, C-reactive protein and monocyte chemoattractant protein-1) in dogs with sepsis to healthy dogs.<h4>Methods</h4>This study was a multicenter observational clinical trial conducted at two university teaching hospitals from February 2016 until July 2017. This evidence concerns the gene SERPINE1 and Sepsis.