NFKB1 and myelodysplastic syndrome: In this study, we show that the risk SNP of TG is associated with the pathogenesis of ICRP in MDs and that the increased expression of TG is associated with the risk allele T/T in the non-inflammatory colonic mucosa, showing that TG possesses a biological role in the activation of NF-κB, which is a critical component of the IL-6 amplifier.