Moreover, catechins exhibit potent free radical scavenging activity, significantly reducing the secretion of IL-1β and IL-6 in C57BL/6 mice induced by MSU crystals, while inhibiting the activation of the NLRP3 inflammasome, thus effectively reducing the likelihood of developing gout in patients (Jhang et al., 2015). The gene discussed is IL1B; the disease is gout.