Three different reports by Miyauchi A., Randle R.W., and Shabina R. analyzed a total of 927 cases of sporadic s-MTC, and all concluded that unilateral thyroidectomy was acceptable for sporadic isolated s-MTC patients with normal contra-lateral thyroid and no RET mutation detected in the reproductive cell line. This evidence concerns the gene RET and medullary thyroid gland carcinoma.