Moreover, inflammatory cytokines secreted by the tumor, such as TGF-β, TNF-α, IL-1, IL-6, IL-8, and IL-10, could induce local inflammation and fibrosis (16), which affect the electrophysiological characteristics of adjacent myocardium of pulmonary veins and atrium, facilitating occurrence of AF. This evidence concerns the gene IL10 and atrial fibrillation.