BRCA1 and ovarian cancer: Women who carry a BRCA1 mutation have a 48.3% (95% CI, 38.8%–57.9%) cumulative risk of ovarian cancer by age 70, whereas carriers of a pathogenic BRCA2 variant have a 20.0% (95% CI, 13.3%–29.0%) cumulative risk by age 70 (8).