Mutations in the genes controlling RNA regulation, SF3B1 (Spicing factor 3b subunit2), SFSF2 (Serine and arginine rich splicing factor 2), and IKZF1 (IKAROS family finger 1) have been described and may affect these processes in myeloid cancers including MPN (14, 15). Here, IKZF1 is linked to myeloproliferative disorder.