Compared to normal tissues, a significant increase in <i>CXCL10</i> and <i>ITGB6</i> (associated with the model) expression was observed in PC tissues.<h4>Conclusion</h4>We first identified the PANoptosis-related molecular subtypes and established a PANoptosis-related prognostic model for predicting the survival of patients with PC. The gene discussed is ITGB6; the disease is pachyonychia congenita.