We also compared HGSOC.Sig with features that were applied in clinical applications (Brca1 mutation, TP53 somatic mutation, tumor stage, tumor grade, and residual cancer size) and showed an AUC of 0.87 for HGSOC.Sig and 0.34–0.67 for other features (Figure 6H). Here, BRCA1 is linked to neoplasm.