GOBP, Hallmark, KEGG, and Reactome analyses of these marker genes showed that pathways associated with tumor promotion, such as activation of the ERAD pathway (46, 47), synthesis of the immunosuppressive cytokine IL-10 (48), and drive of endoplasmic reticulum stress (49), were remarkably enriched in B_C0 (Figures 3G and S3G). Here, IL10 is linked to neoplasm.