CD4 and neoplasm: Previous studies identified several factors associated with chemotherapy outcomes, such as high tumor-infiltrating lymphocyte (TIL) abundance (12), high density of CD8+T cells and LAMP3+ mature dendritic cells (DCs) (13), high CD4+CD68+CD20+ and low CD8+ T-lymphatic infiltration (14), and tumor-infiltrating immune cell (TIIC) abundance (15), correlated with chemotherapy response.