CYLD and nasopharyngeal carcinoma: After the statistical analysis, they found that the tumor suppressor gene CYLD increases the stability and nuclear transportation of p53 by deubiquitination, to downregulate the transcription of phosphofructokinase-2/fructose-2, 6-Diphosphatase 3 (PFKFB3) (53), thus inhibiting the glycolysis process in NPC cells.